Tasnima N, Yu H, Li Y, Santra A, *Chen X. Chemoenzymatic synthesis of para-nitrophenol (pNP)-tagged alpha2–8-sialosides and high-throughput substrate specificity studies of alpha2–8-sialidases. Org. Biomol. Chem. 2017, 15, 160-167. PMID: 27924345. PMCID: PMC5173422. DOI: 10.1039/C6OB02240E.
†Yu H, †Zeng J, Li Y, Thon V, Shi B, *Chen X. Effective one-pot multienzyme (OPME) synthesis of monotreme milk oligosaccharides (MOSs) and other sialosides containing a 4-O-acetyl sialic acid. †These authors contributed equally. Org. Biomol. Chem. 2016, 14, 8586-8597. PMID: 27548611. DOI: 10.1039/C6OB01706A
Khedri Z, Li Y, Muthana S, Muthana MM, Hsiao C-W, Yu H, *Chen X. Chemoenzymatic synthesis of sialosides containing C7-modified sialic acids and their application in sialidase substrate specificity studies. Carbohydr. Res. 2014, 389, 100-111. PMID: 24680514. PMCID: PMC4074090. DOI: 10.1016/j.carres.2014.02.021.
‡Khedri Z, ‡Li Y, Cao H, Qu J, Yu H, Muthana MM, *Chen X. Synthesis of selective inhibitors against V. cholerae sialidase and human cytosolic sialidase NEU2. Org. Biomol. Chem. 2012, 10, 6112-6120. PMID: 22641268. DOI:10.1039/C2OB25335F. ‡Co-first authors.
‡Khedri Z, ‡Muthana MM, ‡Li Y, Muthana SM, Yu H, Cao H, *Chen X. Probe sialidase substrate specificity using chemoenzymatically synthesized sialosides containing C9-modified sialic acids. Chem. Commun. 2012, 48, 3357-3359. PMID: 22361713. DOI:10.1039/C2CC17393J ‡Co-first authors.
Li Y, Cao H, Dao N, Luo Z, Yu H, Chen Y, Xing Z, Baumgarth N, Cardona C, *Chen X. High-throughput neuraminidase substrate specificity study of human and avian influenza viruses. Virology 2011, 415, 12-19. PMID: 21501853. PMCID: PMC3114948. DOI: 10.1016/j.virol.2011.03.024.
Chen G-Y, Chen X, King S, Cavassani KA, Cheng J, Zheng X, Cao H, Yu H, Qu J, Fang D, Wu W, Bai X-F, Liu J-Q, Woodiga SA, Chen C, Sun L, Hogaboam CM, Kunkel SL, *Zheng P, *Liu Y. Amelioration of sepsis by inhibiting sialidase-mediated disruption of CD24-Siglec G interaction. Nat. Biotechnol. 2011, 29, 428-435. PMID: 21478876. PMCID: PMC4090080. DOI:10.1038/nbt.1846.
Sela DA, Li Y, Lerno L, Wu S, Marcobal AM, German JB, Chen X, Lebrilla CB, *Mills DA. An infant-associated bacterial commensal utilizes breast milk sialyloligosaccharides. J. Biol. Chem. 2011, 286, 11909-11918. PMID: 21288901. PMCID: PMC3069393. DOI: 10.1074/jbc.M110.193359.
Li Y, Cao H, Yu H, Chen Y, Lau K, Qu J, Thon V, Sugiarto G, *Chen X. Identifying specific sialidase inhibitors for human cytosolic sialidase NEU2 by substrate specificity studies. Mol. Biosyst. 2011, 7, 1060-1072. PMID: 21206954. PMCID: PMC3114945. DOI: 10.1039/C0MB00244E.
Cao H, Li Y, Lau K,; Muthana S, Yu H, Cheng J, Chokhawala HA, Sugiarto G, Zhang L, *Chen X. Sialidase substrate specificity studies using chemoenzymatically synthesized sialosides containing C5-modified sialic acids. Org. Biomol. Chem. 2009, 7, 5137–5145. PMID: 20024109. DOI: 10.1039/B916305K.
Chokhawala H, Yu H, *Chen X. High-throughput substrate specificity studies of sialidases using chemoenzymatically synthesized sialoside libraries. ChemBioChem 2007, 8, 194–201. PMID: 17195254. PMCID: PMC2610223. DOI: 10.1002/cbic.200600410.