*Yu H, Li Y, Zeng J, Nguyen D, Ly T, Kuang HY, Ngo A, Thon V, *Chen X. One-pot multienzyme (OPME) chemoenzymatic synthesis of glycosphingolipid glycans. J. Org. Chem. 2016, 81, 10809-10824. PMID: 27736072. DOI: 10.1021/acs.joc.6b01905.
†Yu H, †Zeng J, Li Y, Thon V, Shi B, *Chen X. Effective one-pot multienzyme (OPME) synthesis of monotreme milk oligosaccharides (MOSs) and other sialosides containing a 4-O-acetyl sialic acid. †These authors contributed equally. Biomol. Chem. 2016, 14, 8586-8597. PMID: 27548611. DOI: 10.1039/C6OB01706A. †Co-first authors.
Chen C, Zhang Y, Xue M, Liu X, Li Y, *Chen X, *Wang PG, *Wang F, *Cao H. Sequential one-pot multienzyme (OPEM) synthesis of lacto-N-neotetraose and its sialyl and fucosyl derivatives. Chem. Commun. 2015, 51, 7689-7692. PMID: 25848722. DOI: 10.1039/c5cc01330e.
Ding L, Yu H, Lau K, Li Y, Muthana S, Wang J, *Chen X. Efficient chemoenzymatic synthesis of sialyl Tn antigen and derivatives. Chem. Commun. (Camb) 2011, 47, 8691-8693. PMID: 21725542. PMCID: PMC3201767. Web-themed issue on Glycochemistry & Glycobiology. DOI: 10.1039/c1cc12732b.
Yu H, Cao H, Tiwari VK, Li Y, *Chen X. Chemoenzymatic synthesis of C8-modified sialic acids and related alpha2-3- and alpha2-6-linked sialosides. Bioorg. Med. Chem. Lett. 2011, 21, 5037-5040. PMID: 21592790. PMCID: PMC3156331. DOI: 10.1016/j.bmcl.2011.04.083.
Lau K, Yu H, Thon V, Khedri Z, Leon ME, Tran BK, *Chen X. Sequential two-step multienzyme synthesis of sialyl T antigens and derivatives. Org. Biomol. Chem. 2011, 9, 2784-2789. PMID: 21359399. PMCID: PMC3114947. DOI: 10.1039/c0ob01269f.
Huang S, Yu H, *Chen X. Chemoenzymatic synthesis of a2–3-sialylated carbohydrate epitopes. Sci. China Chem. 2011, 54, 117–128. PMID: 21686057. PMCID: PMC3115702. DOI: 10.1007/s11426-010-4175-9.
Yu H, Cheng J, Ding L, Khedri Z, Chen Y, Chin S, Lau K, Tiwari VK, *Chen X. Chemoenzymatic synthesis of GD3 oligosaccharides and other disialyl glycans containing natural and non-natural sialic acids. J. Am. Chem. Soc. 2009, 131, 18467–18477. PMID: 19947630. PMCID: PMC2811049. DOI: 10.1021/ja907750r.
Cao H, Muthana S, Li Y, Cheng J, *Chen X. Parallel chemoenzymatic synthesis of sialosides containing a C5-diversified sialic acid. Bioorg. Med. Chem. Lett. 2009, 19, 5869–5871. PMID: 19740656. PMICD: PMC2753693. DOI:10.1016/j.bmcl.2009.08.078.
Chokhawala HA, Huang S, Lau K, Yu H, Cheng J, Thon V, Hurtado-Ziola N, Guerrero JA, Varki A, *Chen X. Combinatorial chemoenzymatic synthesis and high-throughput screening of sialosides. ACS Chem. Biol. 2008, 3, 567–576. PMID: 18729452. PMCID: PMC2588434. DOI: 10.1021/cb800127n.
Huang S, Yu H, *Chen X. Disaccharides as sialic acid aldolase substrates: synthesis of disaccharides containing a sialic acid at the reducing end. Angew. Chem. Int. Ed. 2007, 5, 2249–2253. PMID: 17309109. DOI: 10.1002/anie.200604799.
Yu H, Chokhawala HA, Varki A, *Chen X. Efficient chemoenzymatic synthesis of biotinylated human serum albumin-sialoglycoside conjugates containing O-acetylated sialic acids. Org. Biomol. Chem. 2007, 5, 2458–2463. PMID: 17637967. PMCID: PMC2769491. DOI: 10.1039/b706507h.
Chokhawala HA. Cao H. Yu H. *Chen X. Enzymatic synthesis of fluorinated mechanistic probes for sialidases and sialyltransferases. J. Am. Chem. Soc. 2007, 129, 10630–10631. PMID: 17696347. DOI: 10.1021/ja072687u.
Yu H, *Chen X. Aldolase catalyzed synthesis of b-D-Gal-(1-9)-D-KDN: A novel acceptor for sialyltransferases. Org. Lett. 2006, 8, 2393–2396. PMID: 16706534. DOI: 10.1021/ol060736m.
Yu H, Huang S, Chokhawala H, Sun M, Zheng H, *Chen X. Highly efficient chemoenzymatic synthesis of naturally occurring and non-natural a-2,6-linked sialosides: a P. damsela a-2,6-sialyltransferase with extremely flexible donor substrate specificity. Angew. Chem. Int. Ed. 2006, 45, 3938–3944. PMID: 16721893. PMCID: PMC2728590. DOI: 10.1002/anie.200600572.
Yu H, Chokhawala H, Karpel R, Yu H, Wu B, Zhang J, Zhang Y, Jia Q, *Chen X. A multifunctional Pasteurella multocida sialyltransferase: a powerful tool for the synthesis of sialoside libraries. J. Am. Chem. Soc. 2005, 127, 17618–17619. PMID: 16351087. DOI: 10.1021/ja0561690.